Use of photodynamic compositions for cytotoxic effects

Details Use of photodynamic compositions for cytotoxic effects Use of photodynamic compositions for cytotoxic effects

1988-12-27

1991-07-02

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424 9, 514 2, 514 61, 514825, 514885, 514908, G01N 3353, C07K 308, A61K 3140

Patent

active

050285947

ABSTRACT:
Hematopoietic cells are selectively eliminated by cytotoxic agents which rely upon light activation. The cytotoxic agents are joined to ligands, particularly sugars, specific for myeloid monocyte and lymphocytic lineages. Further specificity can be achieved by limiting the light target. The method and compositions find particular use in organ transplants and arthritis.

REFERENCES:
patent: 4486538 (1984-12-01), Bogoch
patent: 4672028 (1987-06-01), Olson
patent: 4677056 (1987-06-01), Dupont et al.
patent: 4683295 (1987-07-01), Carson
patent: 4693885 (1987-09-01), Bommer et al.

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