Hydroxamic acid derivatives as metalloproteinase inhibitors

Details Hydroxamic acid derivatives as metalloproteinase inhibitors Hydroxamic acid derivatives as metalloproteinase inhibitors

1997-04-29

1999-01-19

Burn, Brian M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

562801, 562621, 562622, A61K 3119

Patent

active

058614362

ABSTRACT:
The present invention relates to therapeutically active hydroxamic acid derivatives, to pharmaceutical compositions containing them, and to the therapeutic use of these compounds. In particular, the compounds are inhibitors of matrix metalloproteinases that are involved in tissue degradation, and in addition, are inhibitors of the release of tumor necrosis factor from cells.

REFERENCES:
patent: 3468936 (1969-09-01), van der Burg
patent: 4996358 (1991-02-01), Handa et al.
patent: 5183900 (1993-02-01), Galardy et al.
patent: 5300674 (1994-04-01), Crimmin et al.
patent: 5304549 (1994-04-01), Broadhurst et al.

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