Substituted pyridines as selective cyclooxygenase-2 inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514333, 514344, 514345, 514352, 514354, 514356, 514357, 514277, 546257, 546258, 546290, 546300, 546301, 546309, 546311, 546312, 546304, 546314, 546318, 546322, 546339, 546345, 546287, 546286, 546348, A61K 3144, C07D21322

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active

058614192

ABSTRACT:
The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.

REFERENCES:
patent: 5480568 (1996-01-01), Pawloski et al.
patent: 5593994 (1997-01-01), Batt et al.
patent: 5686470 (1997-11-01), Weier

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