Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-02-22
1999-01-19
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 530350, 530412, 530417, 530422, A61K 3816, C07K 1400
Patent
active
058613722
ABSTRACT:
The present invention comprises an aggregate endothelial inhibitor and method of use therefor. The aggregate endothelial inhibitor comprises a protein having a molecular weight of between approximately 45 kilodaltons and 65 kilodaltons as determined by reducing polyacrylamide gel electrophoresis, and having an amino acid sequence substantially similar to that of a murine plasminogen fragment beginning at amino acid number 98 of a murine plasminogen molecule.
REFERENCES:
patent: 4677196 (1987-06-01), Rausch et al.
patent: 4966963 (1990-10-01), Patroni
patent: 5288502 (1994-02-01), McGinity et al.
patent: 5530100 (1996-06-01), Darling et al.
O'Reilly et al. `Angiostatin:A Novel Antgogenesis Inhibior that Mediates the Suppression of Metastases by Lewis Lung Carcinoma`. Cell, vol. 79, pp. 315-328, Oct. 21, 1994.
Folkman J., Tumor angiogenesis: Therapeutic implications., N. Engl. Jour. Med. 285:11832 1186, 1971.
Algire GH, et al. Vascular reactions of normal and malignant tumors in vivo. I. Vascular reactions of mice to wounds and to normal neoplastic transplants. J. Natl. Cancer Inst. 6:73-85, 1945.
Folkman J, et al., Tumor behavior in isolated perfused organs: In vitro growth and metastasis of biopsy material in rabbit thyroid and canine intestinal segments. Annals of Surgery 164:491-502, 1966.
Gimbrone, M.A., Jr. et al., Tumor growth and neovascularization: An experimental model using the rabbit cornea. J. Natl. Cancer Institute 52:41-427, 1974.
Gimbrone MA Jr., et al., Tumor dormancy in vivo by prevention of neovascularization. J. Exp. Med. 136:261-276.
Knighton D., Avascular and vascular phases of tumor growth in the chick embryo. British J. Cancer, 35:347-356, 1977.
Lien W., et al., The blood supply of experimental liver metastases. II. A microcirculatory study of normal and tumor vessels of the liver with the use of perfused silicone rubber. Surgery 68:334-340, 1970.
Folkman J. et al., Induction of angiogenesis during the transition from hyperplasia to neoplastia. Nature 339:58-61, 1989.
Kim K J, et al., Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 362:841-844, 1993.
Hori A, et al., Suppression of solid tumor growth by immunoneutralizing monoclonal antibody against human basic fibroblast growth factor. Cancer Research, 51:6180-6184, 1991.
Gross JL, et al. Modulation of solid tumor growth in vivo by bFGF. Proc. Amer. Assoc. Canc. Res. 31:79, 1990.
Ingber D, et al., Angioinhibins: Synthetic analogues of fumagillin which inhibit angiogenesis and suppress tumor growth. Nature, 48:555-557, 1990.
Weidner N, et al., Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N. Engl. J. Med. 324:1-8, 1991.
Weidner N, et al., Tumor angiogensis: A new significant and independent prognostic indicator in early-stage breast carcinoma, J Natl. Cancer Inst. 84:1875-1887, 1992.
Weidner N, Carroll PR, Flax J, Blumenfeld W, Folkman J. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. American Journal of Pathology, 143(2):401-409, 1993.
Srivastava A, et al., The prognostic significance of tumor vascularity in intermediate thickness (0.76-4.0 mm thick) skin melanoma. Amer. J. Pathol. 133:419-423, 1988.
Nguyen M, et al., Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in urine of bladder cancer patients. J. Natl. Cancer Inst. 85:241-242, 1993.
Robbins, K.C., "The plasminogen-plasmin enzyme system" Hemostasis and Thrombosis, Basic Principles and Practice, 2nd Edition, ed. by Colman, R.W. et al. J.B. Lippincott Company, pp. 340-357, 1987.
Yoshimura, T, et al., "Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on Chromosome 3" J. Biol. Chem.., vol. 268, No. 21, pp. 15461-15468, 1993.
Browne, M.J., et al., "Expression of recombinant human plasminogen and aglycoplasminogen in HeLa cells" Fibrinolysis vol. 5 (4). 257-260, 1991.
Brem et al., "Interstitial chemotherapy with drug polymer implants for treatment of recurrent gliomas," J. Neurosurg. 74:441-446 (1991).
Muthukkaruppan Vr., et al., Angiogenesis in the mouse cornea. Science 205:1416-1418, 1979.
Passaniti A, et al., "A Simple, quantitative method for assessing angiogenesis and anti-angiogenic agents using reconstituted basement membrane, heparin and fibroblast growth factor," Lab. Invest., vol. 67, p. 519 (1992).
Folkman J., Angiogenesis and its inhibitors in "Important Advances in Oncology 1985", VT DeVita, S. Hellman and S. Rosenberg, editors, J.B. Lippincott, Philadelphia 1985.
Obeso, et al., "Methods in Laboratory Investigation, A Hemangioendothelioma-derived cell line; Its use as a Model for the Study of Endothelial Cell Biology," Lab. Invest., 63(2), pp. 259-269, 1990.
Sotrrup-Jensen, L., et al., Progress in Chemical Fibrinolysis and Thrombolysis, vol. 3, Davidson, J.F., et al. eds Raven Press, New York, p. 191 (1978).
Grant, D.S., et al., "Scatter factor induces blood vessel formation in vivo," Proc. Natl. Acad. Sci., vol. 90, pp. 1937-1941 (1993).
Shi, G. et al., "Kringle Domains and Plasmin Denaturation," Biochem. and Biophys. Res. Comm., vol. 178, No. 1, pp. 360-368 (1991).
Scaller, J. et al., "Structural Aspects of the Plasminogen of Various Species," Enzyme., vol. 40, pp. 63-69 (1988).
Wiman, B., et al., "On the Specific Interaction between the Lysine-binding sites in Plasmin and Complementary Sites in <<.sub.2 -Antiplasmin and in Fibrinogen," Biochemica et Biophysica Acta, 579, 142 (1979).
Derwent Publications, Ltd., London; JP 58-036-391 (Sankyo KK) Mar. 3, 1983 (Abstract).
M. O'Reilly et al., "The Suppression of Tumor Metastases by a Primary Tumor" Science vol. 44, pp. 474-476; 1993.
T. E. Maione et al., "Inhibition of Angiogenesis by Recombinant Human Platelet Factor-4 and Related Peptides" Science vol. 247, pp. 77-79; Jan. 5, 1990.
M. A. Moses et al., "Identification of an Inhibitor of Neovascularization from Cartilage" Science vol. 248, pp. 1408-1410; Jun. 15, 1990.
O;Reilly, M.S. Holmgren, L., Shing, Y., Chen, C., Rosenthal, R.A., Moses, M., Lane, W.S., Cao, Y., Sage, E.H., and Folkman, J., Cell (1994) 79:315-328.
Folkman M. Judah
Lin Jie
O'Reilly Michael S.
Gupta Anish
The Children's Medical Center Corporation
Tsang Cecilia J.
LandOfFree
Aggregate angiostatin and method of use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aggregate angiostatin and method of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aggregate angiostatin and method of use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1246660