Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-05-21
1999-01-19
Eisenschenk, Frank C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
5303871, 53038826, 5303892, 435 71, 435 792, 435 793, 435 795, 436506, G01N 3353, C07K 1600
Patent
active
058612645
ABSTRACT:
This invention provides methods of detecting mast cell mediated disease in an individual by detecting the presence in the individual of autoantibodies against mast cell specific proteins, such as tryptase and chymase. Specific mast cell mediated diseases detected by this invention include asthma, rheumatoid arthritis and SLE. The invention also provides a method of detecting autoantibodies against a mast cell specific protein. The method comprises exposing a sample to an sbp member complementary to the autoantibody and detecting the specific binding between the autoantibody and the sbp member. A related aspect of the invention provides methods of treating mast cell mediated diseases by monitoring for the presence of these autoantibodies. Another aspect of the invention relates to a composition comprising an autoantibody against a mast cell specific protein and the mast cell specific protein. A related aspect of the invention is to a method of forming a composition comprising an immune complex of a tryptase autoantibody and tryptase, wherein the complex is bound to a solid support.
REFERENCES:
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Ausubel et al., Current Protocols in Molecular Biology, Green Pub. Assn. and Wiley Interscience. 1992, pp. 11.2.1-11.2.5, Dec. 1991.
Smith, Catherine H., et al., "Mast cell number and phenotype in chronic idiopathic urticaria", J Allergy Clin Immunol, vol. 96, No. 3, pp. 360-364 (Sep. 1995).
Lavery, J.P., "Preliminary study of the tyrptase levels in the synovial fluid of patients with inflammatory arthritis," Division of Rheumatology, Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas, vol. 72, May 1994, pp. 425-427.
Halpern, G.M., "In vitro diagnosis in asthma: the state-of-the-art," Allergie et Immunologie, vol. 23, (1991) pp. 255-262.
Elrod Kyle C.
Tanaka Richard D.
AxyS Pharmaceuticals, Inc.
Eisenschenk Frank C.
Nolan Patrick J.
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