Methods for identifying compounds that modulate mammalian tub pr

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C12Q 100, C12Q 102

Patent

active

058612394

ABSTRACT:
The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the control of mammalian body weight. The nucleic acid molecules of the present invention represent the gene corresponding to the mammalian tub gene, a gene that is involved in the regulation of body weight. The present invention also relates to methods for identifying compounds that modulate tub protein activity.

REFERENCES:
Friedman, J.M. et al., 1991, "Molecular Maping of Obesity Genes", Mamm. Genome 1:130-144.
Bray, G.A., 1992, "Genetic, Hypothalamic and Endocrine Features of Clinical and Experimental Obesity", Prog. Brain Res. 93:333-341.
Friedman, J.M. and Leibel, R.L., 1992, "Tackling a Weighty Problem", Cell 69:217-220.
Coleman, D.L. and Eicher, E.M., 1990, "Fat (fat) and Tubby (tub): Two Autosomal Recessive Mutations Causing Obesity Syndromes in the Mouse", J. Hered. 81:424-427.
Jones, J.M. et al., 1992, "Localization of Insulin-2 (Ins-2) and the Obesity Mutant Tubby (tub) to Distinct Regions of Mouse Chromosome 7", Genomics 14:197-199.
Warden, C.H. et al., 1993, "Coincidence of Genetic Loci for Plasma Cholesterol Levels and Obesity in a Multifactorial Mouse Model", J. Clin. Inves. 92:773-779.
Nishina, P.M. et al., 1994, "Characterization of Plasma Lipids in Genetically Obest Mice: The Mutants Obese, Diabetes, Fat, Tubby, and Lethal Yellow", Metabolism 43:549-553.
Nishina, P.M. et al., 1994, "Atherosclerosis in Genetically Obest Mice: The Mutants Obese, Diabetes, Fat, Tubby, and Lethal Yellow", Metabolism 43:554-558.
Seldin, M.F. et al., "Glycogen Synthase: A Putative Locus for Diet-Induced Hyperglycemia", J. Clin. Invest. 94:269-276.
West, D.B. et al., 1994, "Genetics of Dietary Obesity in AKR/J X SWR/J Mice: Segregation of the Trait and Identification of a Linked Locus on Chromosome 4", Mamm. Genome 5:546-552.
Warden, C.H. et al., 1995, "Identification of Four Chromosomal Loci Determining Obesity in a Multifactorial Mouse Model", J. Clin. Invest. 95:1545-1552.
Samuelson, L.C. et al., 1995, "Localization of the Murine Cholecystokinin A and B Receptor Genes", Mamm. Genome 6:242-246.
Ohlemille, K.K. et al., 1996, "Cochlear and Retinal Degeneration in the tubby Mouse", Neuroreport 6:845-849.
Heckenlively, J.R. et al., 1995, "Mouse Model for Usher Syndrome: Linkage Mapping Suggests Homology to Usher Type I Reported at Human Chromosome 11p15", Proc. Natl. Acad. Sci. USA 92:11100-11104.
Chung, W.K. et al., 1996, "Molecular Mapping of the Tubby (tub) Mutation on Mouse Chromosome 7", Genomics 32:210-217.
Genbank Accession No. X69827 NCBI Entrez Record.
Vambutas, V. and Wolgemuth, D.J., 1994, "Identification and Characterization of the Developmentally Regulated Pattern of Expression in the Testis of a Mouse Gene Exhibiting Similarity to the Family of Phosphodiesterases", Biochim. Biophys. Acta 1217:203-206.
Genbank Accession No. Z48334 NCBI Entrez Record.
Wilson, R. et al., 1994, "2.2 Mb of Contiguous Nucleotide Sequence from Chromosome III of C. elegans", Nature 368:32-38.
Genbank Accession No. Z50688 NCBI Entrez Record.
Genbank Accession No. H92408 NCBI Entrez Record.
Bray, GA, 1989, "1989 McCollum Award Lecture, Genetic and Hypothalamic Mechanisms for Obesity--Finding the Needle in the Haystack" Am. J. Clin. Nur. 50:891-902.
Borjeson, M., 1976, "The Aetiology of Obesity in Children", Acta. Paediatr. Scand. 65:279-287.
Chen, H. et al., "Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice", Cell 84:491-495.
Coleman, D.L., 1978, "Obese and Diabetes: Two Mutant Genes Causing Diabetes-Obesity Syndromes in Mice", Diabetologia 14:141-148.
Grundy and Barnett, 1990, "Metabolic and health complications of obesity", Dis. Mon. 36:641-731.
Heckenlively, 1988, in Retinitis Pigmentosa, Heckenlively, ed., Lippincott, Philadelphia, pp. 221-235.
Herberg and Coleman, 1977, "Laboratory Animals Exhibiting Obesity and Diabetes Syndromes", Metabolism 26:59-99.
Kleyn, P. et al., 1996, "Identification and Characterization of the Mouse Obesity Gene tubby: A Member of a Novel Gene Family", Cell 85:281-290.
Knoll, J.H. et al., 1993, "Cytogenetic and Molecular Studies in the Prader-willi and Angleman Syndromes an Overview", Am. J. Med. Genet. 46:2-6.
Marshall, E., 1995, "Gene Therapy's Growing Pains", Science 269:1050-1055.
Michaud, E. et al., 1994, "Differential Expression of a New Dominant Agouti Allele (A.sup.iapy) is Correlated with Methylation State and is Influenced by Parental Lineage", Genes Devel. 8:1463-1472.
Moll, et al., 1991, "The Genetic and Environmental Sources of Body Mass Index Variability: The Muscatime Ponderosity Family Study", Am. J. Hum. Gen. 49:1243-1255.
Naggert, J. et al., 1995, "Hyperproinsulinaemia in Obese fat/fat Mice Associated with a Carboxypeptidase E Mutation which Reduces Enzyme Activity", Nature Genetics 10:135-141.
Noben-Trauth, K. et al., 1996, "A Candidate Gene for the Mouse Mutation Tubby", Nature 380:534-538.
Leibel, R. et al., 1990, in "Genetic Variation and Nutrition in Obesity", Simopoulos AP, Childs B (eds): Genetic Variation and Nutrition. World Rev. Nutr. Diab. Basel, Karger, Switzerland, vol. 63, pp. 90-101.
Stunkard, 1990, "The Body-Mass Index of Twins Who Have Been Reared Apart", N. Eng. J. Med. 322:1483-1487.
Tartaglia, L.A. et al., 1995, "Identification and Expression Cloning of a Leptin Receptor", Cell 83:1263-1271.
Zhang, Y et al., 1994, "Positional Cloning of the Mouse Obese Gene and its Human Homologue", Nature 372:425-432.
Breen et al., 1994, "Towards high resolution maps of the mouse and human genomes--a facility for ordering markers to 0.1 cM resolution", Human Mol. Genetics 3:621-627.
Dietrich et al., 1992, "A Genetic Map of the Mouse Suitable for Typing Intraspecific Crosses", Genetics 131:423-447.
Kozak, M., 1987, "An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs", Nuc. Acids. Res. 15:8125-8132.
Kunkel, T.A., 1985, "Rapid and efficient site-specific mutagenesis without phenotypic selection", PNAS USA 82:488-491.
Whitney, J.B. III, 1978, "Simplified Typing of Mouse Hemoglobin (Hbb) Phenotypes Using Cystamine", Biochem. Genet. 16:667-672.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for identifying compounds that modulate mammalian tub pr does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for identifying compounds that modulate mammalian tub pr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for identifying compounds that modulate mammalian tub pr will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1245635

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.