Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1995-11-14
1999-01-19
Bawa, Raj
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424484, 424489, 424 781, 426465, A23L 100
Patent
active
058611789
ABSTRACT:
Described are compositions comprising a desired material, e.g., a soluble fiber, entrapped within a protein matrix, and methods of preparation and use thereof. In a preferred embodiment, the subject invention provides a method for entrapping a soluble fiber compound within a protein matrix, wherein the method comprises the following steps: (a) a soluble fiber compound is first mixed with undenatured protein to create a uniform dispersion, wherein the dispersion thus created comprises protein at a concentration of at least about 25% and soluble fiber at a concentration of less than about 75%; (b) the dispersion created in step (a) is then mixed with water and subjected to elevated pressures, wherein the pressures reduce the water content of the composition to less than about 50%, thereby forcing the protein and the soluble fiber compound into close molecular proximity; and (c) the dispersion is then subjected to heat of at least about 300.degree. F., thereby entrapping the soluble fiber compound within the protein matrix, and wherein the heating process reduces the water content of the composition to less than about 5%.
REFERENCES:
patent: 4497838 (1985-02-01), Bonnell
Reiser, S. (1987) "Metabolic Effects of Dietary Pectins Related to Human Health" Food Technology, Feb.: 91-99.
Baekey, P.A. et al. (1988) "grapefruit Pectin Inhibits Hypercholersterolemia and Atherosclerosis in Miniature Swine" Clin. Cardiol. 11:595-600.
Cerda, J.J. et al. (1988) "The Effects of Grapefruit Pectin on Patients at Risk for Coronary Heart Disease Without Altering Diet or Lifestyle" Clin. Cardiology 11:589-594.
Cerda, J.J. et al. (1994) "Inhibition of Atherosclerosis by Dietary Pectin in Microswine With Sustained Hypercholesterolemia" Circulation 89(3):1247-1253.
Cerda, J.J. (1994) "The Pectin-Cholesterol Connection--A Review Technology: Journal of The Franklin Insitute" 331A:199-202.
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