2-Decarboxy-2-hydroxymethyl-cis-4,5-didehydro-PGE, compounds

Details 2-Decarboxy-2-hydroxymethyl-cis-4,5-didehydro-PGE, compounds 2-Decarboxy-2-hydroxymethyl-cis-4,5-didehydro-PGE, compounds

1976-01-08

1977-06-07

Morgenstern, Norman

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603432R, 2603433R, 2603451, 2603452, 2603461R, 2603462R, 260473R, 260473G, 260488R, 260488CD, 260590C, 260599, 260600R, 260613R, 260617R, 260618R, 260618D, 260619D, 260619F, 424305, 424308, 424331, 424343, C07C 4946, C07C 4980, C07C 4982

Patent

active

040284190

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 3810943 (1974-05-01), Jones et al.
patent: 3933892 (1976-01-01), Chadra et al.
Pike "J. Org. Chem.," vol. 34, p. 3552 (1969).
Crabbe et al. "Intra Science Chem. Reports," vol. 6, p. 55, (1972).

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