Process of preparing penicillamine

Details Process of preparing penicillamine Process of preparing penicillamine

1976-02-13

1977-06-07

Evans, Joseph E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603067C, 424269, 426807, C07C 9900

Patent

active

040284069

ABSTRACT:
Improvements in the process of preparing penicillamine or a homolog thereof by reacting an .alpha.-carbon atom branched aldehyde, sulfur and ammonia to form a thiazoline-.DELTA..sup.3, reacting the thiazoline-.DELTA..sup.3 with anhydrous hydrogen cyanide to form a thiazolidine-4-carbonitrile, hydrolyzing the nitrile to form a mixture of the salt of the thiazolidine-4-carboxylic acid and ammonium salts, separating off the ammonium salts and hydrolytically decomposing the thiazolidine-4-carboxylic acid, wherein under the action of a mineral acid the thiazolidine-4-carbonitrile is in the first stage converted at low temperatures into the salt of the thiazolidine-4-carbonamide and then at higher temperatures converted into the salt of the thiazolidine-4-carboxylic acid.

REFERENCES:
Wagner et al., "Synthetic Organic Chemistry", (1953), pp. 412, 413, 570.
Asinger et al., Annual Report of Landesamt fur Forschung des Landes of Nordrhein-Westfalen, (1967), pp. 11-35.

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