Method for producing 1-iodoalkyl acylates

Details Method for producing 1-iodoalkyl acylates Method for producing 1-iodoalkyl acylates

1984-11-21

1986-06-03

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

260408, 560105, 560121, 560123, 560124, 560238, C07C 6714

Patent

active

045931151

ABSTRACT:
An 1-Iodoalkyl acylate, which is useful as the raw material for esterification of cephalosporins, penicillins, etc. is prepared in a high degree of purity and in high yield by (1) allowing a carboxylic acid iodide to react with an aldehyde, or (2) allowing a carboxylic acid chloride to react with a salt of hydriodic acid and then allowing the resulting product to react with an aldehyde, or (3) by simultaneously allowing a carboxylic acid chloride, a salt of hydriodic acid and an aldehyde to react with one another.

REFERENCES:
Noller, Chemistry of Organic Compounds, 2nd ed. 1957, W. B. Saunders Co., Philadelphia; pp.160-161.
Hilgetag and Weygand, Preparative Organic Chemistry 1972, John Wiley & Sons, New York; p. 247.
March, Advanced Organic Chemistry, 2nd ed., McGraw-Hill, New York; pp. 880-881.

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