N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidin

Details N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidin N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidin

1985-07-01

1986-06-03

Michl, Paul R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

260239B, 260239BF, 544130, 544365, 546186, 546188, 546190, 546193, 546194, 546205, 546206, 546208, 546226, 548538, C07D21146

Patent

active

045931020

ABSTRACT:
Novel pyrrolidine, piperidine and homopiperidinecarboxamide and thiocarboxamide compounds having the formula: ##STR1## wherein X is --S--, --S(O)-- or --S(O).sub.2 --; A is a loweralkalene chain and A.sup.1 and A.sup.2 are alkalene chains when p and d are one; R, R.sup.1 and R.sup.2 are hydrogen, loweralkyl, phenyl cycloalkyl or phenylalkyl and R.sup.1 and R.sup.2 may form a heterocyclic residue with the adjacent nitrogen atom; Q is a selected aromatic radical, and the pharmaceutically acceptable acid addition salts useful as cardiac antiarrhythmia agents are disclosed.
Novel chemical intermediates, unsubstituted on pyrrolidine, piperidine and homopiperidine nitrogen but with --(A.sup.2).sub.p --X--(A.sup.2).sub.d --Q side chain are also disclosed.

REFERENCES:
patent: 4374990 (1983-02-01), Weber

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