Pyrimidinecarbamate derivatives as intermediates

Details Pyrimidinecarbamate derivatives as intermediates Pyrimidinecarbamate derivatives as intermediates

1982-07-01

1985-10-22

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544255, 544298, 544320, 544323, 548262, 548333, 548341, C07D23934

Patent

active

045490198

ABSTRACT:
2,4-Disubstituted 6-[3,6-dihydro-1(2H)-pyridyl]pyrimidine-3-oxides of the formula ##STR1## wherein R.sup.1 is lower alkyl or lower alkoxy-lower alkyl, R.sup.2 is hydrogen or --COOR.sup.3 wherein R.sup.3 is lower alkyl or lower alkoxy-lower alkyl,
which are important for the preparation of therapeutically valuable 1,2,5,6-tetrahydropyridyl-substituted 2-oxo-2H-[1,2,4]oxadiazolopyrimidinecarbamates, are described. The foregoing oxides of formula I can be prepared by reacting the corresponding arylsulfonyloxy- or alkylsulfonyl-substituted derivatives with 1,2,5,6-tetrahydropyridine.

REFERENCES:
patent: 3382248 (1968-05-01), Anthony et al.
patent: 3435035 (1969-03-01), Habicht et al.
patent: 4150132 (1979-04-01), Muller et al.
patent: 4176119 (1979-11-01), Muller et al.
patent: 4220772 (1980-09-01), Muller et al.

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