Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
1997-11-11
Davis, Zinna Northington
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546339, C07D21302, A61K 3144
Patent
active
056864736
ABSTRACT:
In accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists, antagonists or allosteric modulators of acetylcholine receptors, and are useful for a variety of therapeutic applications, such as the treatment of Alzheimer's disease and other disorders involving memory loss and/or dementia (including AIDS dementia); disorders of attention and focus (such as attention deficit disorder); disorders of extrapyramidal motor function such as Parkinson's disease, Huntington's disease, Gilles de la Tourette syndrome and tardive dyskinesia; mood and emotional disorders such as depression, panic, anxiety and psychosis; substance abuse including withdrawal syndromes and substitution therapy; neuroendocrine disorders and dysregulation of food intake, including bulimia and anorexia; disorders of nociception and control of pain; autonomic disorders including dysfunction of gastrointestinal motility and function such as inflammatory bowel disease, irritable bowel syndrome, diarrhea, constipation, gastric acid secretion and ulcers; pheochromocytoma; cardiovascular dysfunction including hypertension and cardia arrhythmias, comedication in surgical procedures, and the like.
REFERENCES:
patent: 5175301 (1992-12-01), Minamida et al.
patent: 5399575 (1995-03-01), Friebe et al.
patent: 5418229 (1995-05-01), Alker et al.
Alkondon and Albuquerque, "Diversity of Nicotinic Acetylcholine Receptors in Rat Hippocampal Neurons. III. Agonist Actions of the Novel Alkaloid Epibatidine and Analysis of Type II Current" J. Pharmacol. Exper. Therap. 274:771-782 (1995). Cholinergic Channel Ligand" J. Pharmacol. Exper. Therap. 273:1434-1441 (1995).
Chaki et al., "Design and Syntheses of 4-Acylaminopyridine Derivatives: Novel High Affinity Choline Uptake Enhancers I.sup.1 " Bioorgan. & Med. Chem. Let. 5:1489-1494 (1995).
De Fiebre et al., "Characterization of a Series of Anabaseine-Derived Compounds Reveals That the 3-(4)-Dimethylaminocinnamylidine Derivative Is a Selective Agonist at Neuronal Nicotinic .alpha.7/.sup.125 .vertline.-.alpha.-Bungarotoxin Receptor Subtypes" Mol. Pharmacol. 47:164-171 (1995).
Hansson et al., "On the Quantitative Structure--Activity Relationships of Meta-Substituted (S)-Phenylpiperdines, a Class of Preferential Dopamine D.sub.2 Autoreceptor Ligands: Modeling of Dopamine Synthesis and Release in Vivo by Means of Partial Least Squares Regression" J. Med. Chem. 38:3121-3131 (1995).
Kashiwabara et al., "Comparative Vasodepressor Effects of 3-Pyridine Derivatives Possessing the Cyanoamidine or Amide Structure in Pithed Rats" Arch. int. Pharmacodyn 328:297-306 (1994).
Natsugari et al., "Novel, Potent, and Orally Active Substance P Antagonists: Synthesis and Antagonists Activity of N-Benzylcarboxamide
Cosford Nicholas D.
Vernier Jean-Michel
Davis Zinna Northington
Reiter Stephen E.
SIBIA Neurosciences Inc.
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