Inhibitors of farnesyl-protein transferase

Details Inhibitors of farnesyl-protein transferase Inhibitors of farnesyl-protein transferase

1993-10-27

1997-11-11

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514362, 514365, 546336, 5483385, 562444, 562445, 562448, 562553, 562556, 562557, 562559, C07D21328, C07C38100, C07C72900, A61K 3141

Patent

active

056864728

ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

REFERENCES:
patent: 5043268 (1991-08-01), Stock
patent: 5141851 (1992-08-01), Brown et al.
patent: 5238922 (1993-08-01), Graham
patent: 5326773 (1994-07-01), de Solms
patent: 5340828 (1994-08-01), Graham
patent: 5352705 (1994-10-01), Deana
patent: 5504212 (1996-04-01), de Solms et al.
Kohl, N.E. et al., "Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice", Proc. Natl. Acad. Sci. USA, vol. 91, pp. 9141-9145 (1994).
Goldstein, J.S., et al. Journal of Biological Chemistry, vol. 266, No. 24 pp. 15575-15578 (1991).

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