Thyrotropin-releasing hormone analogs and method of use

Details Thyrotropin-releasing hormone analogs and method of use Thyrotropin-releasing hormone analogs and method of use

1995-01-27

1997-11-11

Scheiner, Toni R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

056864205

ABSTRACT:
A series of novel thyrotropin-releasing hormone analogs wherein the C-terminal prolineamide moiety has been preserved, the N-terminal moiety comprises one of five different ring structures and the histidyl moiety is substituted with CF.sub.3, NO.sub.2 or a halogen. A method of use of the analog for the treatment of neurologic disorders is also provided.

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