Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-04-08
1997-11-11
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 9, 514 14, 514 15, 514 16, 514 12, A61K 3800
Patent
active
056864183
ABSTRACT:
A method of prolonging the survival of pancreatic cells transplanted in a patient. The method includes the step of administering a therapeutically effective amount of a somatostatin or a somatostatin agonist to the patient.
REFERENCES:
patent: 4612302 (1986-09-01), Szabo et al.
patent: 4853371 (1989-08-01), Coy et al.
patent: 4904642 (1990-02-01), Coy et al.
patent: 5538739 (1996-07-01), Bodmer et al.
Bjork et al., "Glucose Regulation of the Autoantigen GAD.sub.65 in Human Pancreatic Islets", Journal of Clinical Endocrinology and Metabolism 76:1574-1576, 1992.
Buhler et al., "Indications for Human Islet Transplantation: Chronic Pancreatitis and Cystic Fibrosis", Transplantation Proceedings 27:3148-3149, 1995.
Eizirik et al., "Prolonged Exposure of Human Pancreatic Islets to High Glucose Concentrations In Vitro Impairs the .beta.-Cell Function", J. Clin. Invest. 90:1263-1268, 1992.
Grunt et al., "A Randomized Trial of a Somatostatin Analog for Preserving Beta Cell Function in Children With Insulin Dependent Diabetes Mellitus", Freund Publishing House Ltd. 7:331-334, 1994.
Kendall et al., "Pancreas and Islet Transplantation", The Endocrinologist 5:28-35, 1995.
Patel et al., "Subtype Selectivity of Peptide Analogs For all Five Cloned Human Somatostatin Receptors (hsstr 1-5)", Endocrinology 135:2814-2817, 1994.
Ponder et al., "Pancreatic Beta Cell Rest Induced by Use of Somatostatin Analog in Newly-Diagnosed Children and Adolescents With Type I Diabetes Mellitus", Metabolism & Diabetes pp. 197A, 1168.
Pozo et al., "Endocrine Profile of a Long-acting Somatostatin Derivative SMS 201-995. Study in Normal Volunteers Following Subcutaneous Administration", Acta Endocrinologica 111:433-439, 1986.
Raynor et al., "Cloned Somatostatin Receptors: Identification of Subtype-Selective Peptides and Demonstration of High Affinity Binding of Linear Peptides", Molecular Pharmacology 43:838-844, 1993.
Reisine et al., "Molecular Biology of Somatostatin Receptors", Endocrine Reviews 16:427-442, 1995.
Robertson, R. Paul, "Pancreatic and Islet Transplantation for Diabetes--Cures or Curiosities?", Seminars In Medicine of the Beth Israel Hospital, Boston 327:1861-1868, 1992.
Rossowski et al., "Specific Inhibition of Rat Pancreatic Insulin or Glucagon Release by Receptor-Selective Somatostatin Analogs", Biochemical & Biophysical Research Comm. 205:341-346, 1994.
Sandler et al., "Effects of Nicotinamide Supplementation on Human Pancreatic Islet Function in Tissue Culture", Journal of Clinical Endocrinology and Metabolism 77:1574-1576, 1993.
Schuit et al., "Regulation of Adenosine 3',5'-Monophosphate Levels in the Pancreatic B Cell", Endocrinology 117:834-840, 1985.
Vlahos et al., "Diabetes Prevention in BB Rats by Inhibition of Endogenous Insulin Secretion", Metabolism 40:825-829, 1991.
Keen, Harry, "Insulin Resistance and the Prevention of Diabetes Mellitus", The New England Journal of Medicine 331:1226-1227, 1994.
Tolis et al., "Active Acromegaly: Selective and Non-Selective Effects on GH and Insulin Release . . . ", The Endocrine Society, 77th Annual Meeting Jun. 14-17, 1995, Washington, DC, Program & Abstract P3-118.
Williams, Gareth, "IDDM: Long Honeymoon, Sweet Ending", The Lancet 343:684-685, 1994.
Steiner et al.; Somatostatin: Progress In Segmental Pancreas Transplantation? An Experimental Study of Canine Duct-Occluded Grafts; Transplant. Proc. (1984), 16(3) Abstract.
Bell Kent L.
Biomeasure Incorporated
Tsang Cecilia J.
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