Polypeptide derivatives

Details Polypeptide derivatives Polypeptide derivatives

Filed on

1994-07-18

Date issued

1997-11-11

Examiner

Hutzell, Paula K.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Peptide containing doai

Other Related Categories

514 2, 530324, A61K 3818, C07K 14485

Type

Patent

Status

active

Patent number

056864108

Description

ABSTRACT:
A biologically active peptide selected from growth factors, peptide hormones, interferons and cytokines and analogues and derivatives thereof, and bearing at least one chelating group linked to an amino group of said peptide, the chelating group being capable of complexing a detectable element and such amino group having no significant binding affinity to target receptors, are complexed with a detectable element and are useful as a pharmaceutical, e.g. a radiopharmaceutical for in vivo imaging of target tissues or for therapy.

REFERENCES:
patent: 4824986 (1989-04-01), Gansow
patent: 4831175 (1989-05-01), Gansow et al.
patent: 4832940 (1989-05-01), Ege
patent: 5037630 (1991-08-01), Fritzberg et al.
patent: 5110904 (1992-05-01), Haviv et al.
Kovacs, M. et al., Effects of long-term administration of a superactive agonistic and an antagonistic GNRH analog on the pituitary-gonad, Peptides (Elmsford) 10, 925-932 (1989). See entire abstract.
Kuranov, I. et al., Amphibian bombesin and its analogue alytesin, Biorg. Khim. 15, 748-762 (1989). See entire abstract.

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