Assymetric synthesis process

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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546255, 546178, C07D40106

Patent

active

055148050

ABSTRACT:
A novel process for the asymmetric hydrogenation of compounds of the formula: ##STR1## wherein R represent aryl or heteroaryl, to compounds of the formula: ##STR2## wherein R has the above significance, is carried out using rhodium-diphosphine complexes.

REFERENCES:
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Noyori, et al., J. Am. Chem. Soc. 110, 629-631 (1988).
Hayashi, et al., Tetrahedron Letters, 425-428 (1979).
Marko, et al., J. Organometallic Chem. 232, C17-C19 (1982).
Achiwa, et al., Tetrahedron Letters, 363-366 (1989).
Sakuraba., Chemical Abstracts, vol. 116, (1992).
Arntz, et al., Catal. Met. Complexes 161-189 (1991).

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