Recovery of oligonucleotides by gas phase cleavage

Details Recovery of oligonucleotides by gas phase cleavage Recovery of oligonucleotides by gas phase cleavage

1994-04-21

1996-05-07

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, 536 2531, 536 2532, 536 2533, 536 2534, C07H 100, C07H 2100

Patent

active

055147895

ABSTRACT:
A process for the cleavage and deprotection of newly synthesized oligonucleotides from solid supports, which involves incubating the solid support in an environment comprising gaseous cleavage/deprotection reagent such as gaseous ammonia or ammonium hydroxide vapors. The method lends itself well to the use of supports such as microtiter plates, that can be used to simultaneously perform up to 96 individual synthetic processes.

REFERENCES:
patent: 4458066 (1988-07-01), Caruthers et al.
patent: 5264566 (1993-11-01), Froehler et al.
patent: 5281701 (1994-01-01), Vinayak
patent: 5393877 (1995-02-01), McLean et al.
"Leroy Hood: Thinking Big in Seattle", Science 264:206-209 (1994).

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