Photocleavable derivatives of hydroxyprenesulfonic acids

Details Photocleavable derivatives of hydroxyprenesulfonic acids Photocleavable derivatives of hydroxyprenesulfonic acids

1994-01-11

1996-05-07

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514576, 514577, 558270, 558271, 562 45, 562 46, 562 70, 562 71, 562 72, 549453, 549454, A61K 31265, A61K 31185, C07C30938, C07C 6996

Patent

active

055147100

ABSTRACT:
The invention describes the synthesis and use of photoactivated (or caged) fluorescent dyes. Upon illumination at less than about 400 nm the caged dyes release highly fluorescent, water soluble hydroxypyrenesulfonic acid dyes according to the following equation: ##STR1## X, Y, and Z are independently sulfonic acid, a sulfonic acid salt, a hydroxyl group, or hydrogen, with at least one of X, Y, and Z being a sulfonic acid or sulfonic acid salt. LINK is either an ether linkage or a carbonate linkage. BLOCK is a caging group whose photolysis results in liberation of a free hydroxypyrenesulfonic acid dye.
The caged fluorescent dyes are useful for application in aqueous solutions, including fluids of biological origin. The caged dyes of the present invention are especially useful for flow tagging velocimetry.

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