Substituted quinoline derivatives useful as antipiconaviral agen

Details Substituted quinoline derivatives useful as antipiconaviral agen Substituted quinoline derivatives useful as antipiconaviral agen

1995-05-24

1996-05-07

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546153, 546155, 546157, 546159, 546162, 546167, 514312, 514313, A61K 3147, C07D40104

Patent

active

055146929

ABSTRACT:
The invention discloses compounds of the formula ##STR1## wherein, Het.sub.1 is chosen from the group consisting of substituted or unsubstituted furyl, oxazolyl, isoxazolyl, oxadiazolyl, tetrazolyl, thiadiazolyl
Y is an alkylene bridge of 3 to 9 carbon atoms.
Het.sub.2 is quinolyl quinolyl substituted by R.sub.1 and R.sub.2 ;
R.sub.1 and R.sub.2 are each individually chosen from hydrogen, halo, alkyl, alkenyl, amino, alkylthio, hydroxy, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinyl alkyl, alkylsulfonylalkyl, alkoxy, nitro, carboxy, alkoxycarbonyl, dialkylaminoalkyl, alkylaminoalkyl, aminoalkyl, difluoromethyl, trifluoromethyl or cyano;
R.sub.3 is alkyltetrazolyl, or substituted or unsubstituted heterocyclyl chosen from benzoxazolyl, benzathiazolyl, thiadiazolyl, imidazolyl, dihydroimidazolyl, oxazolyl, thiazolyl, oxadiazolyl, pyrazolyl, isoxazolyl, isothiazolyl, furyl, triazolyl, tetrazolyl, thiophenyl the N-oxide thereof or a pharmaceutically acceptable acid addition salt thereof are effective antipicornaviral agents.

REFERENCES:
patent: 5436247 (1995-07-01), Sohda et al.

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