Synthetic inhibitors of hepatitis C virus NS3 protease

Details Synthetic inhibitors of hepatitis C virus NS3 protease Synthetic inhibitors of hepatitis C virus NS3 protease

1997-05-09

1999-11-23

Mosher, Mary E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530327, 530332, 530402, 435183, 435212, 435219, 435236, 514 13, 514 14, 514 15, 930 10, 930 21, 930 30, 930220, C07K 700, C07K 702, C07K 708, C07K 1400

Patent

active

059902760

ABSTRACT:
An inhibitor of the HCV NS3 protease. The inhibitor is a subsequence of a substrate of the NS3 protease or a subsequence of the NS4A cofactor. Another inhibitor of the present invention contains a subsequence of a substrate linked to a subsequences of the NS4A cofactor. In another embodiment the inhibitor is a bivalent inhibitor comprised of a subsequence, a mutated subsequence or a mutated full-length of a substrate of the NS3 protease linked to a subsequence, a mutated subsequence or a mutated full-length suquence of the HCV NS4A cofactor.

REFERENCES:
patent: 5371017 (1994-12-01), Houghton et al.
patent: 5372928 (1994-12-01), Miyamura et al.
patent: 5767233 (1998-06-01), Zhang et al.
patent: 5843752 (1998-12-01), Dasmahapatra et al.
Shimuzu et al (1996) J of Virology, vol. 70 (1) PP. 127-132.
Urbani et al (1996) J Biol. Chem., vol. 272 (14) pp. 9204-9209.
Okamoto et al., 1990, J. Exp. Med, 60(3):167-77.
Bartenschlager et al., 1995, J. Virology, 69(1):198-205.
Bartenschlager et al., 1994, J. Virology, 68(8):5045-55.
Bourdon et al., 1991, FEBS, 294(3):163-66.
Failla et al., 1995, J. Virology, 69(3):1769-77.
Lin et al., 1994, J. Virology, 68(12):9147-57.
Maraganore et al., 1990, Biochemistry, 29:7095-7101.
Parry et al., 1994, Biochemistry, 33:14807-14.
Pizzi et al., 1994, PNAS, 91:888-92.
Tanji et al., 1995, J. Virology, 69(3):1575-81.

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