Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-11-03
1999-11-23
Carr, Deborah D
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514449, 514461, 514463, 564123, 564199, 549450, 549451, 549452, A01N 4326, A61K 31335
Patent
active
059901586
ABSTRACT:
New therapeutic agents of carboxylic acid derivatives are disclosed, which are represented by the compounds of the following formula (I) or its pharmaceutically acceptable salts, ##STR1## These compounds are useful as a matrix metalloproteinases (MMPs) inhibitors.
REFERENCES:
Casreact Abstr. of JP-04/149170, 1995.
Organic Chemistry, 9th ed., pp. 183 & 313, 1995.
M.R. Gowravaram, et al. "Inhibition of Matrix Metalloproteinases by Hydroxamates Containing Heteroatom-Based Modifications of the P.sub.1 ' Group", J. Med. Chem., 1995, 38, pp. 2570-2581.
B.E. Tomczuk, et al., "Hydroxamate Inhibitors of the Matrix Metallo-Proteinases (MMPs) Containing Novel P.sub.1 ' Heteroatom Based Modifications", Biorganic & Medicinal Chem. Letters, vol. 5, No. 4, pp. 343-348 (1995).
Kobayashi Yoshinori
Noda Atsushi
Tomiyama Akira
Tomiyama Tsuyoshi
Yanagisawa Takashi
Carr Deborah D
Kotobuki Seiyaku Co. Ltd.
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