Method for treating tumors having high LDL requirements employin

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514326, 514329, A61K 31495, A61K 31445

Patent

active

059901101

ABSTRACT:
A method is provided for treating hematologic tumors and solid tumors, including certain types of leukemias and metastatic tumors, having high LDL requirements employing a delipidating agent such as an MTP inhibitor to substantially reduce LDL blood levels. In addition, a method is provided for treating tumors of the above types having high LDL requirements, especially hematologic tumors such as certain leukemias, employing a delipidating compound to substantially remove native LDL, and then administering a cytotoxic agent carried in reconstituted LDL.

REFERENCES:
patent: 5712279 (1998-01-01), Biller et al.
Firestone, R.A. "Low-Density Lipoprotein as a Vehicle for Targeting Antitumor Compounds to Cancer Cells" Bioconjugate Chem., vol. 5, No. 2, 1994, pp. 105-113.
Wunderlich, M. et al, "The Redox Properties of Protein Disulfide Isomerase (DsbA) of Escherichia coli Result from a Tense Conformation of its Oxidized Form", J. Mol. Biol. (1993) 233, 559-566.
Firestone, R.A. et al, "Selective Delivery of Cytotoxic Compounds to Cells by the LDL Pathway" Journal of Medicinal Chem., 1984, vol. 27, No. 8, pp. 1037-1043.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for treating tumors having high LDL requirements employin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for treating tumors having high LDL requirements employin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating tumors having high LDL requirements employin will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1222133

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.