Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-07-15
1999-11-23
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514326, 514329, A61K 31495, A61K 31445
Patent
active
059901101
ABSTRACT:
A method is provided for treating hematologic tumors and solid tumors, including certain types of leukemias and metastatic tumors, having high LDL requirements employing a delipidating agent such as an MTP inhibitor to substantially reduce LDL blood levels. In addition, a method is provided for treating tumors of the above types having high LDL requirements, especially hematologic tumors such as certain leukemias, employing a delipidating compound to substantially remove native LDL, and then administering a cytotoxic agent carried in reconstituted LDL.
REFERENCES:
patent: 5712279 (1998-01-01), Biller et al.
Firestone, R.A. "Low-Density Lipoprotein as a Vehicle for Targeting Antitumor Compounds to Cancer Cells" Bioconjugate Chem., vol. 5, No. 2, 1994, pp. 105-113.
Wunderlich, M. et al, "The Redox Properties of Protein Disulfide Isomerase (DsbA) of Escherichia coli Result from a Tense Conformation of its Oxidized Form", J. Mol. Biol. (1993) 233, 559-566.
Firestone, R.A. et al, "Selective Delivery of Cytotoxic Compounds to Cells by the LDL Pathway" Journal of Medicinal Chem., 1984, vol. 27, No. 8, pp. 1037-1043.
Bristol-Meyers Squibb Company
Henley III Raymond
Rodney Burton
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