Dioxolenylmethyl carbamates pro moieties for amine drugs

Details Dioxolenylmethyl carbamates pro moieties for amine drugs Dioxolenylmethyl carbamates pro moieties for amine drugs

1994-07-18

1995-11-14

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544132, 544148, 544362, 544363, 548202, 548465, 549229, C07D40512, C07D31708, C07D41312, C07D27720

Patent

active

054668115

ABSTRACT:
This invention relates to a the use of new oxodioxolenylmethyl carbamates to produce bioreversible neutral prodrugs from primary and secondary amines.

REFERENCES:
patent: 4760057 (1988-07-01), Alexander
Alpegiani et al. Chem. Abst. 117:69628 (1992).
Miyauchi et al., Chem. Abst. 113:190997 (1990).
Sakamoto et al., Chem. Pharm Bull, vol. 33 (1985) 4870-4877.
Saari et al., J. Med. Chem. 1984, 27, 713-717.
Miyauchi et al. Chem. Pharm. Bull. 38(4), 1077-78 (1990).

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