Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Patent
1993-07-06
1995-11-14
Rotman, Alan L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
544124, 544360, 546193, 546250, 546281, C07D41304, C07D40104, C07D21309, C07D21106
Patent
active
054668000
ABSTRACT:
2,5-Disubstituted pyridines of the formula ##STR1## can be prepared by reacting enamines of the formula ##STR2## with .beta.-amino-acrylonitriles of the formula ##STR3## and treating the open-chain intermediate, which represents a R-R.sup.1 -5-amino-penta-2,4-dienonitrile, with protic acids or with ammonia.
REFERENCES:
patent: 4319024 (1982-03-01), Peeters et al.
patent: 4348396 (1982-09-01), Kierstead et al.
patent: 4405552 (1983-09-01), Miesel
patent: 4849432 (1989-07-01), Shiokawa et al.
S. Marchalin et al., "The Use of 4-R.sup.1 -Benzylidene . . . and 2-Amino-4H-Pyrans", Collection Czechoslovak Chem. Commun., vol. 48, pp. 3123-3129 (1983).
H. U. Sieveking et al., "Preparation of Enamino . . . with LiAlH.sub.4 ", Angew. Chem. internat. Edit., vol. 8, p. 458 (1969).
Y. Akiyama et al., "Studies on Conjugated . . . with Enamines", Chem. Pharm. Bull., vol. 32(7), pp. 2821-2824 (1984).
J. P. Ferris et al., "Photochemcial Reactions . . . Nicotinamide Derivatives", Science, vol. 166, pp. 765-766 (1969).
Tetrahedron (24) (1968), pp. 3369-3378.
Synthesis 1985, pp. 1116-1118.
Bayer Aktiengesellschaft
Rotman Alan L.
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