Self-assembling polynucleotide delivery system comprising dendri

Details Self-assembling polynucleotide delivery system comprising dendri Self-assembling polynucleotide delivery system comprising dendri

1995-06-07

1999-11-23

Degen, Nancy

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435455, A61K 3170, A61K 4800, C12N 1587

Patent

active

059900890

ABSTRACT:
A self-assembling polynucleotide delivery system comprises a dendrimer polycation aiding in the delivery of the polynucleotide to a desired address, and optionally other agents such as DNA masking agents, cell recognition agents, charge-neutralization agents, membrane-permeabilization agents, and subcellular-localization agents.

REFERENCES:
patent: 5661025 (1997-08-01), Szoka et al.
patent: 5714166 (1998-02-01), Tomalia et al.
Crystal "Transfer of Genes to Humans: Early Lessons and Obstacles to Success" Science 270: 404-410, Oct. 1995.
Gura "Antisense has Growing Pains" Science 270: 575-577, Oct. 1995.
Stull et al. "Antigene, Ribozyme and Aptamer Nucleic Acid Drugs: Process and Prospects" Pharm. Res. 12: 465-483, Apr. 1995.

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