Human ena/VASP-like protein splice variant

Details Human ena/VASP-like protein splice variant Human ena/VASP-like protein splice variant

1999-01-08

1999-11-23

Saunders, David

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530350, 530849, A61K 3817, C07K 14435

Patent

active

059900873

ABSTRACT:
The invention provides a human ena/VASP-like protein splice variant (EVL1) and polynucleotides which identify and encode EVL1. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of EVL1.

REFERENCES:
Ohta, S, et al., Differential display cloning of a novel rat cDNA (RNB6) that shows high expression in the neonatal brain revealed a member of Ena/VASP family. Biochem. Biophys. Res. Comm. 237:307-312, 1997.
Gertler, F.B. et al., "Mena, a Relative of VASP and Drosophila Enabled, Is Implicated in the Control of Microfilament Dynamics" Cell (1996) 87:227-239.
Ermekova, K.S. et al., "WW Domain of Neural Protein FE65 Interacts with Proline-rich Motifs in Mena, the Mammalian Homolog of Drosophila Enabled" J. Biol. Chem. (1997) 272:32869-32877.
Linial, M., "Proline clustering in proteins from synaptic vesicles" Neuroreport (1994) 5:2009-2015.
Ohta, S. et al., "Differential Display Cloning of a Novel Rat cDNA (RNB6) That Shows High Expression in the Neonatal Brain Revealed a Member of Ena/VASP Family" Biochem. Biophys.Res.Commun. (1997) 237:307-312.
Gertler, F.B. et al., (GI 1644452), GenBank Sequence Database (Accession U72519), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. (1996).
Walter, U., (GI 624963), GenBank Sequence Database (Accession Z46389), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. (1995).
Haffner, C. et al., "Molecular cloning, structural analysis and functional expression of the proline-rich focal adhesion and microfilament-associated protein VASP" EMBO J. (1995) 14:19-27.
Adams, M.D., et al., GenBank Accession No. AA312190, cross reference to Nature 377, supp. 28:3-17, 1995.
Naeve, C.W. et al., Accuracy of Automated DNA sequencing: a multi-laboratory comparison of sequencing results. Biotechniques. 19(3) :448-453. (1995).
Gertler, F.B., et al., GenBank Accession No. U72519, cross referenced to Cell 87(2) :227-239 (1996).

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