Inhibin-HBc fusion protein

Details Inhibin-HBc fusion protein Inhibin-HBc fusion protein

1998-05-04

1999-11-23

Kemmerer, Elizabeth

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530399, 536 234, 435 697, C07K 1400, C07K 1402, C07K 14575, A61K 3816

Patent

active

059900857

ABSTRACT:
A fusion protein formed of an antigenic inhibin peptide inserted into hepatitis B capsid protein is expressed from a chimeric gene forming an effective immunogen which induces anti-inhibin antibodies when administered to a host animal.

REFERENCES:
Borisova, et al. Proc. USSR Acad. Sci., 1988; 298:1474-1478 (no title).
Borisova, et al. FEBS Lett., "Recombinant core particles of hepatitis B virus exposing foreign antigenic determinants on therir surface", 1989; 259:121-124.
Borisova, et al. Intervirology, "Spatial structure and insertion capacity of immunodominant region of hepatitis B core antigen", 1996; 39:16-22.
Brown, et al. J. Reprod. Fertility, "Immunization against recombinant bovine inhibin .alpha.-subunit causes increased ovulation rates in gilts", 1990; 90:199-205.
Devereux, et al. Nucleic Acids Res., "A comprehensive set of sequence analysis programs for the VAX", 1984; 12:387-395.
Furst, et al. Gene, 1986; 48:119-131 (no title).
Good, et al. Biol. Reprod., "Isolation of nine different biologically and immunologically active molecular variants of bovine follicular inhibin", 1995; 53:1478-1488.
Ireland, et al. Biol. Reprod., "Alterations in amounts of different forms of inhibin during follicular atresia", 1994; 50:1265-1276.
King, et al. J. Animal Science, "Ovulatory and endocrine responses after active immunization of gilts against a synthetic fragment of bovine inhibin", 1993; 71:975-982.
Martin, et al. Biol. Reprod., "Immunoneutralization of inhibin modifies hormone secretion and sperm production in bulls", 1991; 45:73-77.
Mason, et al. TIBTECH, "Transgenic plants as vaccine production systems", 1995; 13:388-392.
McCue, et al. Theriogenology, "Ovulation and embryo recovery rates following immunization of mares against an inhibin alpha-subunit fragment", 1992; 38:823-831.
Morris, et al. J. Reprod. Fertility, "Effect of immunization against synthetic peptide sequences of bovine inhibin .alpha.-subunit on ovulation rate and twin-calving rate in heifers", 1993; 97:255-261.
Nassal, et al. Trends in Microbiology, "Hepatitis B virus replication", 1993; 1:221-228.
Ohsawa, et al. Anal. Biochem., "Silver stain for detecting 10-femtogram quantities of protein after polyacrylamide gel electrophoresis", 1983; 135:409-415.
Ouchterlony 1965, In:Immunochemie. 15.sup.th Colloquium of the Gesellschaft fur Physiologische, Chemie, Springer, Berlin, Heidelberg, New York, 1979; pp. 15-35.
Scott, et al. Science, "Searching for peptide ligands with an epitope library", 1990; 249:386-390.
Towbin, et al. PNAS USA, "Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications", 1979; 76:4350-4354.
Voglmayr, et al. Biol. Reprod., "Immunization of rams against human recombinant inhibin .alpha.-subunit delays, augments, and extends season-related increase in blood gonadotropin levels", 1990; 42:81-86.

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