Chemistry: analytical and immunological testing – Biological cellular material tested
Patent
1997-08-28
1999-11-23
MacMillan, Keith D.
Chemistry: analytical and immunological testing
Biological cellular material tested
436124, 436503, 435 11, 435 12, 514832, 514743, 514746, 514744, 514759, 604 4, G01N 3348, A01N 2900
Patent
active
059899182
ABSTRACT:
A method for analyzing the ADME/PK properties of a mixture of compounds is (1) perfusing an animal or organ with a perfluorocarbon emulsion blood substitute, (2) administering the mixture of test compounds, (3) withdrawing an aliquot of the perfusate, (4) disrupting the emulsion, and (5) analyzing the aqueous phase of the perfusate for the concentration of test compounds.
REFERENCES:
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Dietz Corine M.
Gibbons Jacqueline A.
Taylor Eric W.
Blackburn Robert P.
Chiron Corporation
Fujita Sharon M.
MacMillan Keith D.
Ponnaluri P.
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