N-substituted .alpha.-amino acids and derivatives thereof having

Details N-substituted .alpha.-amino acids and derivatives thereof having N-substituted .alpha.-amino acids and derivatives thereof having

1991-04-22

1993-01-12

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514119, 558169, 558170, C07F 9145, C07F 9117, A61K 3166

Patent

active

051790858

ABSTRACT:
N-substituted .alpha.-amino acids and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in selectively blocking the N-methyl-D-aspartate (NMDA) excitatory amino acid receptors in mammals and also are useful in treating cerebrovascular disorders such as cerebral ischemia or cerebral infarction resulting from thromboembolic or hemorrhagic stroke, cerebral vasospasm, hypoglycemia, cardiac arrest, status epilepticus and cerebral trauma as well as for treating schizophrenia, epilepsy, neurodegenerative disorders, Alzheimer's disease or Huntington's disease and also additionally useful as anesthetics in surgical procedures where a finite risk of cerebrovascular damage exists.

REFERENCES:
patent: 4616005 (1986-10-01), Karanewsky et al.
patent: 4654429 (1987-03-01), Balthazor et al.
patent: 4746653 (1988-05-01), Hutchinson et al.
patent: 4918064 (1990-04-01), Cordi et al.
patent: 4963539 (1990-10-01), Delaney
Morrison and Boyd, Organic Chemistry, (Boston, Allen and Bacon, 1979) pp. 738 to 740.

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