Antibacterial composition and method of use

Details Antibacterial composition and method of use Antibacterial composition and method of use

1992-04-08

1995-11-14

Sayala, Chhaya D.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 946, 424 945, A61K 3846

Patent

active

054664497

ABSTRACT:
A composition having antibacterial effects is disclosed which comprises the dimeric forms of lysozyme and a pharmaceutically acceptable carrier. These dimeric forms are more effective in treating a variety of human and animal diseases because they are much less cytotoxic than the monomeric forms of the enzyme. A method for the use of these compositions is also disclosed which comprises applying an effective amount of the composition to the infected area.

REFERENCES:
Zinsser Microbiology, Ed. Jokkik et al., Chapters 2 and 53, Publishers Appleton & Lange, 1992.
DeSoize, B. et al., "In vitro cytohikic activity . . . ", J. Pharm. Pharmacol. vol. 38, (1986) pp. 8-13.
Ueda, Tadashi et al., "An Intramolecular Cross-Linkage of Lysozme . . . ", Biochemistry, vol. 24 (1985) pp. 6316-6322.
Caircchini, S., "Use of high-dose lysozyme . . . " Minerva Med., 75 (9-10), 1984 pp. 457-462.
Bartholeyns et al., "In vitro and In vivo Tumore Effect . . . ", Europ J Cancer, vol. 15 (4), 1979 pp. 85-91.
Kooistra et al., "Effect of size and charge on Endocytosis . . . ", Biochimica et Biophysica Acta, 631 (1980), pp. 439-450.
Enzyme Nomenclature, Academic Press, 1984, pp. 302-303.
Bartholeyns, Chem. Abs. 84.173704v, "Cytestatic oropertis . . . ".
D'Alessio et al. Chem. Abs. 132193x, 1974 "Action of dimeric hybrids . . . " vol. 81(21), Nov. 1974.
Tarnowski et al., Cancer Re. 36, Nov. 1976, pp. 4074-4078.
Studebaker et al., JACS 93:18 Sep. 8, 1971, pp. 4581-4585.
Bartholeyns et al., Chem. Abs. 197030w, 1989, "Effects of cross-linked . . . " vol. 96(23), Biochem. J., 202(2) pp. 543-50, 1982.
Sorrentino et al., Europ. J. Biochem vol. 124 No. 1, 1982 pp. 183-189.
The Biochemical Society,. "Effects of Cross-Linked Dimers of Ribonuclease A for of Lysozyme on the Processing of Endocytosed Peroxidase by Hepatoma Cells", J. Bartholeyns et al. vol. 202, 1982, 543-550.

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