Coumaran derivatives and their pharmaceutical use

Details Coumaran derivatives and their pharmaceutical use Coumaran derivatives and their pharmaceutical use

1987-12-22

1989-08-15

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514320, 514338, 514365, 514397, 514462, 514468, 514469, 546196, 546269, 548203, 548204, 548336, 549220, 549336, 549457, 549458, 549462, 549470, A61K 3134, C07D30779

Patent

active

048575160

ABSTRACT:
A compound of the formula ##STR1## wherein R is a lower alkyl group, R.sup.0 is hydrogen or an acyl group, R.sup.1 and R.sup.2 are lower alkyl groups which may optionally be substituted or wherein R.sup.1 and R.sup.2 are combined to form a butadienylene group which may optionally be substituted, R.sup.3 and R.sup.4 are hydrogen or alkyl groups which may optionally be substituted or wherein R.sup.3 and R.sup.4 are combined to form a polymethylene group, and R.sup.5 is a lower alkyl, aromatic or heterocyclic group which may optionally be substituted or a pharmaceutically acceptable salt thereof, exerts cardiovascular system improving action and antiallergic action and can be used as pharmaceutics, e.g. antithromotics, antiallergic agents etc.

REFERENCES:
patent: 2421811 (1947-06-01), Smith et al.
Smith et al., J.A.C.S. vol. 61, pp. 2615-2618 (1939).
Chemical Abstracts, vol. 72, No. 78857r, p. 384, 1970.
Chemical Abstracts, vol. 97, No. 38822e, pp. 569-570, 1982.
Chemical Abstracts, vol. 91, No. 140672z, p. 642, 1979.
Journal of the American Chemical Society, vol. 105, 1983, pp. 5950-5951.
Journal of the American Chemical Society, vol. 107, No. 24, 1985, "Autoxidation of Biological Molecules", pp. 7053-7065.

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