Stabilized standards and calibrators containing rapamycin and ta

Details Stabilized standards and calibrators containing rapamycin and ta Stabilized standards and calibrators containing rapamycin and ta

1996-09-27

1998-04-07

Feisee, Lila

Chemistry: analytical and immunological testing

Composition for standardization, calibration, simulation,...

436 10, 436 11, 436 16, 436 17, 436 18, 436501, 530350, G01N 33536, G01N 3100, C07K 1614

Patent

active

057364010

ABSTRACT:
The present invention is directed to an in vitro aqueous composition comprising a drug, preferably tacrolimus or rapamycin, having enhanced stability. The invention utilizes a binding protein, preferably FKBP, to stabilize the drug in an aqueous matrix.

REFERENCES:
Connelly, et al., "Heat capacity and hydrophobic interactions in the binding of FK506 and rapamycin to the FK506 binding protein", Proc. Natl. Acad. Sci. USA, Jun. 1992, vol. 89, pp. 4781-4785.
Aldape, J. Biol Chem 267:16029, 1992.
Rotonda, J. Biol Chem 268(11):7607-09, 1993.
Jin, Proc. Natl Aca Sci 90:7769, 1993.
Fruman, FASEB 8:391-400 1994.

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