Human integral membrane protein

Details Human integral membrane protein Human integral membrane protein

1997-01-31

1999-03-30

Scheiner, Toni R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 4352523, 4353201, C07H 2104, C12N 1563, C12N 121

Patent

active

058891706

ABSTRACT:
The present invention provides a novel human integral membrane (IMP-2) and polynucleotides which identify and encode IMP-2. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding IMP-2 and a method for producing IMP-2. The invention also provides for agonists, antibodies, or antagonists specifically binding IMP-2, and their use, in the prevention and treatment of diseases associated with expression of IMP-2. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding IMP-2 for the treatment of diseases associated with the expression of IMP-2. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding IMP-2.

REFERENCES:
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Gillies, et al. Human Antibod & Hybridomas 1(1):47-54, 1990.
Hillier,L. et al. GenBank, Accession Nos. AA 149631 and N51010, 1995.
Burgess et al. J. Cell Biol 11: 2129-2138, 1990.
Database EMBL, entry HS690212, Accession No. H62690, Oct. 11, 1995.
Database EMBL, entry HS393355, Accession No. W67393, Jun. 16, 1996.
Database EMBL, entry HSHG2998, Accession No. D45302, Dec. 29, 1995.
Singer, S.J. et al., "The structure and insertion of integral proteins in membranes", Annu. Rev. Cell Bio., 6: 247-296 (1990).
Deleersnijder, W. et al., "Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction", J. Biol. Chem., 271: 19475-19482 (1996).

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