Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai
Patent
1996-08-19
1999-03-30
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heavy metal containing doai
514504, 514578, 514825, 514855, A61K 31305, A61K 31285, A61K 31185
Patent
active
058890483
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/RU94/00128, filed Jun. 15, 1994 published as WO95/22336, Aug. 24, 1995.
FIELD OF THE INVENTION
The preset invention relates to medicine and, more particularly, it relates to novel immunomodulator having regeneration effect on abnormal function of cell tissue division-regulating system.
DESCRIPTION OF THE PRIOR ART
Known in the art is a variety of immune response-modulating agents. Thus for example, the capacity of stimulating immune responses in the body (including lenkopoiesis) exibits nucleic acid derivatives; the capacity of activating specifically immunocompetent cells (T and B-lymphocytes) have pyrogenal, prodigiosan and the like. It is well known that levamisole, (-) 2,3,5,6-tetrahydro-6-phenylimidazo.vertline.2,1-b.vertline.-thiazole hydrochloride can stimulate selectively the regulatory T-lymphocyle function, enhance poor reaction of cell-mediated immunity, supress brisk antibody response, with it having no effects on normal reaction (M. D. Mashkovsky, "Pharmacinticals", Moscow, "Medicine", 1992, V. 2, p. 169-170)
There is also known in the art a medicinal agent, thymaline (complex of polypeptide fractions isolated from cattle thymas gland), which can regulate T and B lymphocyte production, stimulate the cell-mediated immune responses and promote regeneration processes (M. D. Mashkosvsky, "Pharmaceuticals", Moscow, "Medicine", 1992, V. 2, p. 171)
This medicinal agent is used as an immunostimulant and biostimulant in treatment of disorders associated with weakning the cell-mediated immunity including acute chronic purulent processes and inflammations, burn disease. It is also suited to use to use at conditions associated with suppression of immune and blood formation function in oncologic patients after a radiation therapy or chemotherapy.
However, all of the above-mentioned medicinal agents are faulty for their selective action, toxicity, a number of adverse effects and contradictions for administration.
It is well known by those skilled in the art that a key stage of tumor formation is associated with failure of cell division-regulating system.
There are a great variety of antineoplastic agents that are compounds having different chemical structures. Such compounds can be synthesized via chemical reactions or they can be prepared by isolation of biologically active substances from raw materials of vegetable and animal origin (M. D. Mashkovsky, "Pharmaceuticals", Moscow, "Medicine", 1992, v.2, pp. 423-468). Such antineoplastic agents include cyclophosphamide, sarcolysine, mustargen, caryolysine and the like. The alkylating properties of such agents are of considerable importance in mechanism of their action. They are capable of reacting with nucleophilic centers of protein molecules such that DNA synthesis is disturbed, resulting in abnormal vital activity of cells and inhibition of their mytotic division.
Known in the art are antitneoplastic ethylenimine-containing agents such as thiophosphamide, dipine, benzoteph and the like which are compounds that have cytostatic and suppressive effect on proliferating tissue including malignant tissue.
The disturbance of nucleic acids metabolism and the blocking of mitotic cell division are of great concern in the mechanism of action of such medicinal agents.
Among antineoplastic agents, a few of antibiotics are in wide use, more particularly semi-synthetic derivatives wherein nuclei of molecules from the known antitumor antibiotics are used. The effector mechanism of such medicinal agents is associated with selective inhibition of DNA-dependent RNA synthesis, resulting in disturbance of nucleic acid production.
However, most of antitumor agents mentioned above are faulty for their high toxicity, adverse effects (suppression of blood formation). No antineoplastic agents which could regenerate the defective function of cell tissue division-regulating system has previously been reported.
Mercury-containing compounds are widely used in medicine as antiseptics, such as mercury dichloride. Known in the art is the use of arsen
REFERENCES:
patent: 4104373 (1978-08-01), Sichert
CA 94:317, Herr et al, 1980.
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