Prophylactic or therapeutic drug for renal diseases

Details Prophylactic or therapeutic drug for renal diseases Prophylactic or therapeutic drug for renal diseases

1997-11-06

1999-03-30

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514394, A61K 3141, A61K 31415

Patent

active

058890360

ABSTRACT:
This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I) ##STR1## wherein R.sup.1 stands for H or an optionally substituted hydrocarbon residue; R.sup.2 stands for an optionally esterified carboxyl group; R.sup.3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R.sup.2 ; Y stands for a bond, --O--, --S(O).sub.m -- (wherein m stands for 0, 1 or 2), or --N(R.sup.4)-- (wherein R.sup.4 stands for H or an optionally substituted alkyl group).

REFERENCES:
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patent: 5196444 (1993-03-01), Naka et al.
patent: 5250554 (1993-10-01), Naka et al.
Kohara et al., "Angiotensin Blockade and the Progression of Renal Damage in the Spontaneously Hypertensive Rat", Hypertension, 21, 6:975-979 (1993).
Honma et al., "Renal protective effects of the angiotensin II(Ang II) receptor antagonist CV-11974 . . . ", JASN, 4:513 (1993).
Bohm et al., "The Angiotensin II Antagonist BIBR277 Normalized Blood Pressure and Improves . . . ", The FASEB Jnl., 7,3:A246 (1993).
Wolf, et al., "Glucose-Induced Hypertrophy in Cultured Proximal Tubule Cells: Enhancement by Angiotensin II (AII)", The FASEB Jnl., 5,5:A1039 (1991).
Dunn, "Prostaglandins, Angiotension II, and Proteinuria", Nephron, 5:30-37 (1990).
Noda et al., "Inhibition of Rabbit Aortic Angiotensin II (AII) Receptor by CV-11974, A New Nonpeptide All Antagonist", Bio, Pharm., 46,2:311-318 (1993).

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