Substituted heterocycles

Details Substituted heterocycles Substituted heterocycles

1996-04-23

1999-03-30

Dees, Jose'G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546186, 546187, 514316, 514317, A61K 31445, C07D21100

Patent

active

058890246

ABSTRACT:
Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, Q.sup.4 and Q.sup.5 have any of the meanings given in the specification, their N-oxides, and their pharmacuetically acceptable salts are nonpeptide antagonists NKA, useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.

REFERENCES:
patent: 4782061 (1988-11-01), Kruse et al.
patent: 5236921 (1993-08-01), Emonds-Alt et al.
patent: 5300648 (1994-04-01), Emonds-Alt et al.
patent: 5340822 (1994-08-01), Emonds-Alt et al.
patent: 5411971 (1995-05-01), Emonds-Alt et al.
patent: 5434158 (1995-07-01), Shah
A. Graham et al., "Isolation and Characterisation of the Human Lung NK-2 Receptor Gene Using Rapid Amplification of cDNA Ends", Biochemical and Biophysical Research Communications, (1991), vol. 177, No. 1, 8-16.
X. Emonds-Alt et al., "Pharmacological Profile and Chemical Synthesis of SR48968, a Non-Peptide Antagonist of the Neurokinin A (NK.sub.2) Receptor", Bioorganic & Medicinal Chemistry Letters, (1993), vol. 3, No. 5, 925-930.
D. Aharony et al., "Pharmacologic Characterization of the Novel Ligand Hamster Urinary Bladder Membranes", Neuropeptides, (1992), 23, 121-130.
M. Needham et al., "LCR/MEL: A Versatile System for High-Level Expression of Heterologous Proteins in Erthyroid Cells", Nucleic Acids Research, (1992), vol. 20, No. 5, 997-1003.

Affiliated with

Also associated with

Rating

Substituted heterocycles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted heterocycles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted heterocycles will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1215466