Regulation of vascular smooth muscle cell heme oxygenase-1

Details Regulation of vascular smooth muscle cell heme oxygenase-1 Regulation of vascular smooth muscle cell heme oxygenase-1

1997-03-31

1999-03-30

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424450, A61K 39395, A61K 4800, C12Q 102, C12Q 168

Patent

active

058889825

ABSTRACT:
The invention features a method of inhibiting sepsis-associated hypotension in a mammal which includes the steps of identifying a mammal suffering from or at risk of developing sepsis and administering to the mammal a compound which inhibits expression of inducible heme oxygenase (HO-1). Also disclosed are screening assays useful for identifying a compound capable of inhibiting HO-1 expression or enzymatic activity.

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