Dermatalogical compounds and compositions

Details Dermatalogical compounds and compositions Dermatalogical compounds and compositions

1976-05-21

1977-02-08

Demers, Arthur P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260351, 260476C, 424242, 424308, 424309, C07C 6978

Patent

active

040072711

ABSTRACT:
Mono-, di- or tri-(X,Y-substituted-benzoyl) esters of 1,8,9-trihydroxyanthracene, wherein the anthracene moiety can be substituted by methyl at the 3-position, X is halogen, hydroxy, nitro, lower-alkyl, lower-alkoxy, phenoxy, trifluoromethyl, lower-alkylcarboxy or lower-alkoxycarbonyl and Y is hydrogen or has the meaning given hereinabove for X, are prepared by reacting the appropriate 1,8,9-trihydroxyanthracene with the appropriate substituted-benzoic acid or functional derivative thereof, e.g., acid chloride, in an inert solvent, in the presence of a suitable basic catalyst, e.g., pyridine or triethylamine, and under an inert atmosphere. Pharmaceutical compositions comprising these esters are useful in treating dermatological conditions such as psoriasis and have the improvements of having substantially no undesirable staining and irritating properties.

REFERENCES:
patent: 1935928 (1933-11-01), Zahn
Schultz, Chem. Abstracts, 45 (1951) Col. 7751b.

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