Neurotropic growth factors comprising a homeobox peptide

Details Neurotropic growth factors comprising a homeobox peptide Neurotropic growth factors comprising a homeobox peptide

1994-05-05

1999-03-30

Jagannathan, Vasu

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 697, 4352401, 514 2, 514 44, 530300, C12P 2106, C07K 14475, C12N 500

Patent

active

058887628

ABSTRACT:
The invention relates to a method for introducing a macromolecule comprising at least the helix 3 of a homeobox peptide into a living cell. In particular the macromolecule is active as a cell growth factor, in particular a neurotrope.

REFERENCES:
Daniele Derossi et al, "The Third Helix of the Antennapedia Homeodomain Translocates Through Biological Membranes," The Journal of Biological Chemistry, vol. 269, No. 14, pp. 10444-10450 (Apr. 8, 1994).
Isabelle le Roux et al, "Neurotrophic Actiity of the Antennapedia Homeodomain Depends on its Specific DNA-Binding Properties," Proc. Natl. Acad. Sci. USA, vol. 90, pp. 9120-9124 (Oct. 1993).
E. Bloch-Gallego et al, "Antennapedia Homeobox Peptide Enhances Growth and Branching of Embryonic Chicken Motoneurons in Vitro," The Journal of Cell Biology, vol. 120, No. 2, pp. 485-492 (Jan. 1993).
F. Perez et al, "Antennapedia Homeobox as a Signal for the Cellular Internalization and Nuclear Addressing of a Small Exogenous Peptide," Journal of Cell Science, vol. 102, pp. 717-722 (1992).
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Nourse et al 1990 Cell 60: 535-545.
Joliot et al 1991 New Biologist 3(11) : 1121-1134.
Muller et al 1988 EMbO J 7(13); 4299-4304.
Le Maitre et al 1987 PNAS 84: 648-652.
Joliot et al 1991 PNAS 88: 1864-1868.

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