Methods and compositions for treating gastric disorders using op

Details Methods and compositions for treating gastric disorders using op Methods and compositions for treating gastric disorders using op

1996-12-23

1999-03-30

Barts, Samuel

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424451, 424464, 514338, A61K 9127

Patent

active

058885358

ABSTRACT:
Methods and compositions are disclosed utilizing optically pure (-) pantoprazole for the treatment of ulcers in humans while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of pantoprazole. The optically pure (-) isomer is also useful for the treatment of gastroesophageal reflux. (-) Pantoprazole is an inhibitor of H.sup.+ release and is therefore useful in the treatment of other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.

REFERENCES:
patent: 4758579 (1988-07-01), Kohl et al.
Kromer et al J.Pharm. Exp. Ther. 254,129-135,1990.

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