Protein D-an IgD-binding protein of Haemophilus influenzae

Details Protein D-an IgD-binding protein of Haemophilus influenzae Protein D-an IgD-binding protein of Haemophilus influenzae

1997-09-25

1999-03-30

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

530350, 436513, 4241841, 4241851, A61K 39102, A61K 3900, C07K 100, G01N 33563

Patent

active

058885170

ABSTRACT:
A novel surface exposed protein of Haemophilus influenzae or related Haemophilus species is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 encapsulated and non-encapsulated isolates of H. influenzae studied. The protein from all strains shows in addition to the same apparent molecular weight immunogenic similarities since protein D from all strains interacts with three different mouse monoclonal antibodies and monoclonal human IgD. A method for purification of protein D is described. Cloning of the protein D gene from H. influenzae in E. coli is described as well as the nucleotide sequence and the deduced amino acid sequence.

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