Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1982-06-07
1984-06-12
Padgett, Benjamin R.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
424 9, 436548, 436 73, 436 74, 436 84, 436804, 436819, 128 11, 128659, G01N 3360, A61K 4300, A61K 4902
Patent
active
044541066
ABSTRACT:
Therapeutic and diagnostic methods employing metal chelate conjugated monoclonal antibodies are described. Metals employed in therapeutic conjugated antibodies include alpha particle, beta particle or Auger electron emitting isotopes. Diagnostic methods may be either in vivo or in vitro. Chelated metals employed in diagnostic techniques may include, inter alia, gamma or positron emitting metals as well as fluorogenic or paramagnetic metals.
REFERENCES:
patent: 3961038 (1976-06-01), Benes
patent: 4196265 (1980-04-01), Koprowski et al.
patent: 4283382 (1981-08-01), Frank et al.
patent: 4311688 (1982-01-01), Burchiel et al.
patent: 4323546 (1982-04-01), Crockford et al.
patent: 4331647 (1982-05-01), Goldenberg
patent: 4339426 (1982-07-01), Meares et al.
patent: 4348376 (1982-09-01), Goldenberg
patent: 4361544 (1982-11-01), Goldenberg
patent: 4364920 (1982-12-01), Winchell
Pritchard, J. H. et al., Proc. Soc. Experiment. Biology and Medicine, vol. 151, pp. 297-302, (1976).
Scheinberg et al., Science, vol. 215, pp. 1511-1513, (3-19-1982).
Khaw, B. A. et al., Science, vol. 209, p. 295, (1980).
Scheinberg et al., Monoclonal Antibodies in Drug Development, Amer. Soc. Pharm. Exp. Therap., (1981), (Applicants).
Scheinberg et al., "Leukemic Cell Targeting and Therapy by Monoclonal Antibody in a Mouse Model System," (1982), Cancer Research 42: 44-49.
Scheinberg et al., "Targeting in Erytholeukemic Mice: Radioiodinated and Chelated Radiometal-Conjugated Monoclonal Antibody," in Monoclonal Antibodies in Drug Development, pp. 159-171, (J. T. August ed. 1982).
Hnatowich et al., Int'l. J. App. Radiat. Isot., 33: 326-332, (1982).
Scheinberg et al., Science, 215: 1151-1153, (1982).
Paik et al., J. Nuc. Med., 22: 32 (1981).
Krejcarek et al., Biochem. Biophys. Res. Commun., 77: 581 (1977).
Meares et al., Proc. Natl. Acad. Sci. USA, 73: 3803-3806, (1976).
Paik et al., J. Radioanal. Chem., 57: 553-564, (1980).
Bloomer et al., Science, 212: 340-341, (1981).
Zucchini et al., Int. J. Nucl. Med. & Biol., 9: 83-84, (1982).
Gansow Otto A.
Strand Mette
Moskowitz M.
Padgett Benjamin R.
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