Production of 2,6-diaminonebularines

Details Production of 2,6-diaminonebularines Production of 2,6-diaminonebularines

1980-03-28

1981-10-06

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 23, 536 25, C07H 1916, C07H 1918

Patent

active

042936900

ABSTRACT:
Compounds of the formula ##STR1## wherein R is phenyl which may be substituted; or their acid addition salts, are produced in good yield by reacting a compound of the formula ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3, independently of one another, are hydroxyl which may be protected, which is prepared in 2 or 3 steps from 5-amino-1-.beta.-D-ribofuranosylimidazole-4-carboxamide, with a compound of the formula ##STR3## wherein R has the same meaning as defined above and X is amino which may be substituted or lower alkylthio, and, if necessary subjecting the resulting compound to a treatment for removal of protective groups on its hydroxyls.

REFERENCES:
patent: 3134778 (1964-05-01), Weinstock et al.
patent: 3826803 (1974-07-01), Tolman et al.
patent: 3857842 (1974-12-01), Asai
patent: 3936439 (1976-02-01), Marumoto et al.
patent: 4056674 (1977-11-01), Robins et al.

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