Process for the preparation of tertiary carbinols containing an

Details Process for the preparation of tertiary carbinols containing an Process for the preparation of tertiary carbinols containing an

1995-05-24

1998-07-07

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540450, 540609, 548570, 549435, 564320, C07B 4900, C07D21122

Patent

active

057771251

ABSTRACT:
A process for the preparation of tertiary diphenyl carbinols containing a primary or secondary amine substituent on the aliphatic moiety attached to the carbinol function which consists in contacting a Grignard phenyl reagent with an aminoacid wherein the mobile protons are not masked in an aprotic inert organic solvent or a mixture thereof at a temperature between 20.degree. C. and the boiling temperature by the reaction mixture.
The reaction products are useful as active ingredients of medicaments and intermediates for the manufacture thereof.

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