Process for the preparation of imidazolyl macrolide immunosuppre

Details Process for the preparation of imidazolyl macrolide immunosuppre Process for the preparation of imidazolyl macrolide immunosuppre

1996-07-23

1998-07-07

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D49116

Patent

active

057771057

ABSTRACT:
Imidazolmethyloxy-substituted tricyclo-macrolide immunosuppressants are prepared by reacting a tricyclo-macrolide with an imidazolmethyl trichloroacetimidate in the presence of an acid. The invention further provides a crystalline salt of imidazolmethyloxy-substituted tricyclo-macrolide, as well as novel compounds useful in the process of the present invention.

REFERENCES:
patent: 5247076 (1993-09-01), Goulet et al.
patent: 5252732 (1993-10-01), Sinclair et al.
patent: 5344925 (1994-09-01), Goulet et al.
Hamamichi, N.; Migasaka, T., Tet. Lett., 26, pp. 4743-4746 (1985).
Nakajima, N.; Horita, K.; Abe, R.; Yonemitsu, O., Tet. Lett., 33, pp. 4139-4142 (1988).

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