Potentiators of antimicrobial activity

Details Potentiators of antimicrobial activity Potentiators of antimicrobial activity

1996-04-05

1998-07-07

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514192, 514210, 514724, A61K 31045, A61K 31395, A61K 3143, A61K 3162

Patent

active

057769192

ABSTRACT:
The present invention provides antimicrobial compositions, especially compositions comprising an antimicrobial (microbiocidal or microbiostatic) compound and a potentiator of antimicrobial activity. Compositions of the invention combining an antimicrobial compound and a potentiator are able to kill or inhibit the growth of microorganisms using much lower concentrations of the antimicrobial compound. The potentiator also enhances the efficacy of antimicrobial compounds against resistant strains of the microorganism.

REFERENCES:
patent: 5380763 (1995-01-01), Sato et al.
patent: 5587358 (1996-12-01), Sukigara et al.
Demain et al. Antibiotics Containing the Beta-Lactam Structure, vol. 1, Berlin: Springer-Verlag 1983, p. 21.
Himejima et al. Antibacterial Agents from the Cashew . . . J. Agric. Food. Chem. 1991, vol. 39, No. 2, pp. 418-421.
Horikawa et al. Penicillin-Binding Proteins in Bacillus . . . J. Antibiotics, Jun. 1980, vol. 33, pp. 614-619.
Kubo et al. Antibacterial Activity of Long-Chain Alcohols . . . J. Agric. Food Chem. 1993, 161.41, No. 12, pp. 2447-2450.
Kubo et al. Structure-Antibacterial Activity Relationships . . . J. Agric. Food Chem. 1993, vol. 41, No. 6, pp. 1016-1019.
Muroi et al. Bactericidal Activity of Anacardic Acids J. Agric. Food Chem. 1993, vol. 41, No. 10, pp. 1780-1783.
Gellerman et al. Antimicrobial effects of anacardic acids. Can. J. Microb. 1969, vol. 15, pp. 1219-1223.

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