Topical treatment of psoriasis with imidazole antibiotics

Details Topical treatment of psoriasis with imidazole antibiotics Topical treatment of psoriasis with imidazole antibiotics

1983-12-09

1986-02-11

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514396, 514863, 514864, A61K 3150, A61K 31495

Patent

active

045699356

ABSTRACT:
A method is provided for treating psoriasis and seborrheic dermatitis in humans by topical application of an effective, lesion reducing amount of an imidazole antibiotic to affected areas.

REFERENCES:
patent: 4172947 (1979-10-01), Warner et al.
patent: 4205071 (1980-05-01), Durant et al.
patent: 4358449 (1982-11-01), Heeres et al.
Physicians Desk Reference (PDR), 34th ed., 1980, p. 1561.
"Treatment of Pityriasis Capitis (Dandruff) with Econazole Nitrate," Acta Dermatovener (Stockholm), vol. 57, pp. 77-80 (1977)--Article discusses a dandruff treatment with Econazole Nitrate and discusses a causal relationship between fungal infestation and dermatological disorders.
"Activation of the Alternative Pathway of Complement by Malassezia Ovalis (Pityrosporum Ovale)," Mycopathologia, vol. 70.3, pp. 187-191 (1980)--Article discusses a mechanism for seborrheic dermatitis.
"Effect of Topical Applications of Heavy Suspensions of Killed Malassezia Ovalis on Rabbit Skin", Mycopathologia, vol. 72, pp. 147-154 (1980)--Article discusses experimentation leading to an explanation of human psoriasis.
"Sabouraud and Rivolta were Right--Seborrheic Dermatitis is Microbial", Cosmetics and Toiletries, Aug. 1981--Article discusses a mechanism for seborrheic dermatitis.

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