Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1997-06-11
1998-07-07
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435325, 4353201, 4352523, 43525233, 4352541, 4351723, 435 691, 536 232, C12N 1555, C12N 1563, C12N 100, C12N 510
Patent
active
057767530
ABSTRACT:
The invention provides a human peroxisomal thioesterase (PxTE) and polynucleotides which identify and encode PxTE. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PxTE.
REFERENCES:
Smith, S. "Long-chain fatty acyl-S-4'-phosphopantetheine-fatty acid synthase thioester hydrolase from rat." Methods Enzymol. (1981) 71:181-188.
Smith, S. "Medium-chain fatty acyl-s-4'-phosphopantetheine-fatty acid synthase thioester hydrolase from lactating mammary gland of rat." Methods Enzymol. (1981) 71:188-200.
Naggert, J. et al., "Cloning, Sequencing, and Characterization of Escherichia coli Thioesterase II" J. Biol. Chem. (1991) 266(17):11044-11050 (GI 147932).
Baumgart, E. et al., "Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome." Proc.Natl.Acad.Sci. USA (1996) 93:13748-13753.
Watkins, P. et al., "Distinction Between Peroxisomal Bifunctional Enzyme and Acyl-CoA Oxidase Deficiencies." Ann.Neurol. (1995) 38:472-477.
Fang, H. et al., "The Homologue of Mammalian SPC12 is Important for Efficient Signal Peptidase Activity in Saccharomyces cerevisiae." J.Biol.Chem. (1996) 271(28) :16460-16465. (GI 854594).
Corley Neil C.
Hillman Jennifer L.
Shah Purvi
Billings Lucy J.
Bugaisky Gabriele C.
Incyte Pharmaceuticals Inc.
Wax Robert A.
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